The star of the third day's play was seasoned seamer R Vinay Kumar, who returned impressive figures of 5/28 to lay Vidarbha low.
At the Moti Bagh Stadium, Karnataka resumed their second innings from their overnight score of 108/3, an overall lead of 199 runs. They were all out for 209, but not before putting themselves in the driver's seat.
Shrikant Wagh (4/59) and Lalit Yadav (3/90) were the most successful bowlers for Vidarbha.
Overnight on 45, opener Ravikumar Samarth got out after scoring two runs, while Stuart Binny was dismissed for 12.
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In Vidarbha's second innings, Jitesh Sharma (61)was the only batsman to have made a substantial contribution, as the rest crumbled without a fight.
Wagh (13) was the only other batsman to reach double digit.
Points: Karnataka 3, Vidarbha 1.