Half centuries by opener Mayank Agarwal, M Kaunain Abbas, C M Gautam and Shreyas Gopal helped Karnataka to the dominating position as they closed out the day at 395 for 6 in 122 overs with Shreyas Gopal unbeaten on 80 off 151 balls along with skipper R Vinay Kumar (31 not out).
Karnataka had yesterday bundled out Mumbai for a partly 173 and finished the opening day at 115 for 1.
Debutant right arm medium pacers Shivam Malhotra, who grabbed the wicket of Agarwal this morning, and Shivam Dube (5 for 79) were the wicket takers for Mumbai.
In fact, the two first-timers took four wickets in good time to leave Karnataka at 218 for five and the game in balance before the batting side recovered through two big partnerships for the sixth and seventh wickets, with Shreyas Gopal involved in both of them.
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Later, he added 74 runs with skipper Vinay Kumar, who took six wickets yesterday including a hat-trick, for the unfinished seventh wicket to put his team on top and for Karnataka to press on further tomorrow.
For Mumbai, Dube caught the eye in his first Ranji game and his victims included opener R Samarth (40), Abbas, Karun Nair, Pavan Desphande and Gautam.
Senior pacer Dhawal Kulkarni, youngster Akash Parkar and left-arm spinner Karsh Kothari were unsuccessful.
Brief Scores: Mumbai 173 all out v Karnataka 395 for 6 (M Agarwal 78, K Abbas 50, S Gopal 80 not out, CM Gautam 79, R Vinay Kumar 31 not out; S Dube 5-79.