In the sixth over, Lewis went for a lofted straight drive off Bhuvneshwar Kumar but a mix-up between skipper Virat Kohli and Mohammad Shami saw the opportunity go waste.
Four balls later, Lewis gave another chance when he heaved at a Kuldeep Yadav delivery but got a reprieve when an onrushing Karthik, at long-off, couldn't get into the position.
"If mis-hits go for sixes then you know it is his day but he gave us two chances, we couldn't hold on to them. Those were costly opportunities and in T20 games every opportunity would cost you a lot. We could see the result went their way mostly because of dropped chances," Karthik said at the post- match press conference.
"I didn't want to bump into him and that took a fraction of second for me which made me run more than I should and that kind of didn't get me in good position and that's is the reason I dropped the catch," he said.
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India posted 190-6 on a belter but opener Lewis slammed an unbeaten 125 off 62 balls to take West Indies home in just 18.3 overs.
"All said and done, 190 is a good score. On any given day most teams will take 190. But the way the guy played, he hit more sixes than fours. It doesn't happen too many times that you end up hitting twice the number of sixes than boundaries," he said.
"It goes to show he was hitting the ball really well. He was targetting areas that we were confident about. Lot of good balls, he was hitting for boundaries, so it is not easy to bowl. It was one of those days when not much was done by us as a bowling unit but those kind of days happen in T20," he added.
"Given the opportunities given to me, I am trying to do my best. It is a highly competitive team, we have got to put our best foot forward and keep performing and I am trying to do that consistently. My aim is to pile on the runs whenever I get an opportunity, that's what I am trying to focus on," he said.
All-rounder Hardik Pandya couldn't feature in the T20 match after suffering an injury during the warm-up and Karthik said he was missed by the team.
Karthik said overall, the team has done well this year.
"Credit to us as well. We are coming from a big tournament in champions Trophy and come back and put same intensity and performance through the West Indies tour has been good.
"Overall, it has been good year for most players and great opportunity for all to learn and I'm sure we will keep going forward," he said.
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