The party patriarch also urged such "disgruntled" elements to put the party ahead and consider that Karunanidhi himself was contesting from all 234 seats.
In a letter to partymen, Karunanidhi said there could have been disappointments over not nominating a particular individual or changing the candidature of another.
He urged them to "not mind" the disappointments as there was no other option.
The party workers should work with the intention of promoting DMK in all seats, he said.
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The DMK chief said senior leaders like Arcot N Veerasamy, a former Minister, and L Ganesan, had sought seats for their sons, but the party could not accommodate them.
"But these (leaders) and many others like them work for the party's welfare irrespective of whether they get those (desired) opportunities," he said.
DMK has been jolted by open dissent over the high command's choice of candidates for many constituencies and protests are being held in different parts.
The party has also revised its candidates list thrice so far.