The study demonstrates that ambient temperatures can influence the growth or loss of brown fat in people. Cool environments stimulate growth, warm environments loss, researchers said.
Brown fat, also known as brown adipose tissue, is a special kind of fat that burns energy to generate heat.
It keeps small animals and babies warm, and animals with abundant brown fat are protected from diabetes and obesity.
How brown fat is regulated in people, and how it relates to metabolism, have been unclear.
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Lee's previous studies have shown that people with plentiful brown fat stores tend to be lean and have low blood sugar levels. His studies have also shown - in the laboratory - that ordinary human white fat cells can change into brown fat cells.
For the new study, 5 healthy men were recruited and exposed to four month-long periods of defined temperature - well within the range found in climate-controlled buildings.
They lived their normal lives during the day, and returned each night to the centre, staying for at least 10 hours in a temperature-regulated room.
The temperature was then moved down to 19 degrees Celsius for the second month, back to 24 degrees Celsius for the third month, and up to 27 degrees Celsius for the fourth month.
At the end of each month, participants underwent a detailed 'thermal metabolic evaluation' in a whole room calorimeter.
Independent of the season during which the study was carried out, brown fat increased during the cool month and fell during the warm month.
"The big unknown until this study was whether or not we could actually manipulate brown fat to grow and shrink in a human being. What we found was that the cold month increased brown fat by around 30-40 per cent," said Lee.
"During the second thermo-neutral month at 24 degrees, the brown fat dropped back, returning to baseline. When we put the temperature up to 27 degrees during the fourth month, the volume of brown fat fell to below that of baseline," said Lee.