The 28-year-old 'Fashion Police' host's line will also include plus size clothing, reported Ace Showbiz.
"I had one of the most exciting meetings of my life this week - it pretty much green-lit my clothing line. When I sat down in this meeting and they said, 'Yes, you have creative control and of course you can do plus size,' I was like, 'It's happening!'," she said.
Osbourne, 28, explained that her works would contain a bit of her unique style.
"It still has to be very me - quirky," she said, adding that her preference might not work for everyone. "(But) that's me, so I have to (also) have something slightly normal.