The Harvard Crimson bronze medallion, measuring 38 millimetres in diameter, features a raised Harvard seal - a quill and a scroll.
The medallion, which was personally owned by Kennedy, also has raised lettering on the front, reading: "1873, The Harvard Crimson." The reverse is engraved, "John F Kennedy, '40."
"One of Kennedy's prized personal possessions, this remarkable Harvard Crimson pendant derives from his important college years and is a true museum-quality piece," according to the RR Auctions in the US.
In 1940, Kennedy graduated from Harvard with a Bachelor of Arts in government, concentrating on international affairs.
His thesis, 'Appeasement in Munich,' about British participation in the Munich Agreement, soon became a bestseller under the title Why England Slept.
He criticised the British 'appeasement' toward Nazi Germany in a letter published in the Crimson on June 9, 1940, in which he observed: 'The failure to build up her armaments has not saved England from a war, and may cost her one. Are we in America to let that lesson go unlearned?'.