Obama will host recently elected Muhammadu Buhari, the president of Nigeria -- Africa's most populous nation and biggest economy -- at the White House today.
On Thursday, he will jet to Nairobi, and from there trace the Great Rift Valley northward to Addis Ababa, becoming the first US president to visit Ethiopia.
The first African-American president of the United States has visited his ancestral continent four times while in office, but has not yet traveled to Kenya during his White House tenure.
A pipe-smoking economist, he walked out when Obama was just two and died in a car crash in Nairobi in 1982, aged 46.
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Obama's planned "homecoming" was long delayed by Kenyan President Uhuru Kenyatta's indictment for war crimes by the International Criminal Court.
Those charges, linked to ethnic violence, were suspended last year -- in part, prosecutors say, because the Kenyan government thwarted the investigation.
But the suspension has paved the way for the landmark visit and a meeting between the two men.
Trade and security are expected to dominate political discussions. But there will also be a personal and symbolic flavor, even down to the meeting with Kenyatta.
Obama's father was an economist in the government of Kenyatta's father Jomo, who led Kenya at independence from Britain until his death 14 years later in 1978.
The two men did not get on well, with Kenyatta senior sacking Obama senior, and blackballing him for further government jobs, an ostracization that would help fuel alcoholism.
Obama has sometimes struggled to burnish his legacy on the continent, as the "Great Recession," crises in the Middle East, terrorism and a "pivot to Asia" have all sucked up time and effort.