Resuming on 288 for three, Andhra were bowled out for 431 in reply to Kerala's first innings total of 486.
Bodapati Sumanth scored 90 while Murumulla Sriram made 82 for the visitors.
For Kerala, Vinoop Manoharan picked four wickets while C Shahid and P Parameswaran got three and two scalps respectively.
The hosts, in their second innings, were 89 for three with Sanju Samson scoring 51 not out.
Brief Scores:
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Kerala: 486 & 89/3 (Sanju Samson 51 not out; Amol Mazumdar 1/11)
Points: Kerala 3, Andhra 1.