Besides Rohan Prem, who had scored a double hundred in Kerala's first innings, left-arm spinner Karaparambil Monish was the other star of the game as he returned a match haul of 11 wickets.
At stumps on the fourth and final day at the Rajiv Gandhi International Stadium, Hyderabad were 176 for seven in 77 overs.
After putting up 401 all out in their first innings, Kerala bowled out the hosts for 218, with Monish returning impressive figures of six for 91.