Making his fourth trip to Israel since he began his tenure in February, Kerry was to head straight into talks with Israeli Prime Minister Benjamin Netanyahu before travelling to Ramallah to meet Palestinian president Mahmud Abbas.
The meetings come after a long day of diplomacy in Jordan, during which he met with 10 other foreign ministers from the "Friends of Syria" group in a bid to try to end the Syrian conflict.
But despite public declarations of support for his efforts, frustrations have been welling up from both sides.
"Kerry has a lot of good intentions and a real sense of mission" but in practice "looks like a naive and ham-handed diplomat who has been acting like a bull in the china shop of the Israeli-Palestinian conflict," a columnist wrote last week in the Israeli daily Haaretz.
Also Read
And in an interview with Palestinian press, Hanan Ashrawi, Palestine Liberation Organisation executive committee member, said she saw "no readiness" on the Israeli part for a resumption of talks.
Kerry however seems committed to his push, and after whirlwind talks Thursday and Friday, will return to the region on Monday to attend the World Economic Forum in Amman.
He has been seeking to put together a plan for the economic revival of the West Bank and it is possible he could unveil his ideas at the forum.