The tiny sultanate in the South China Sea, where he will attend the Association of Southeast Asian Nations Regional Forum, is the last stop on Kerry's two-week tour of seven countries in Asia and the Middle East.
He landed today morning in Brunei's capital, Bandar Seri Begawan, after flying overnight from Tel Aviv, where he spent four days in long meetings trying to get Israel and the Palestinians back to the negotiating table.
"I am actually anxious to get there and to engage with him because the situation in Syria is grave," Kerry said yesterday in Tel Aviv.
Russia is a key backer of embattled Syrian President Bashar Assad, who is fighting rebel forces who have been being armed by the US and other nations.
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Kerry is also slated to have talks on the sidelines of the meeting with his counterparts in China, Japan, South Korea and other Asian nations.
North Korea is expected to send its longtime foreign minister, 80-year-old Pak Ui Chun, to the conference, and nations attending the forum are expected to reiterate a call for denuclearizing the Korean Peninsula. Many want North Korea to abide by its obligations under UN Security Council resolutions and commitments it made following six-party talks in 2005.
Other issues expected to loom large in Brunei are the South China Sea territorial disputes and relations between the US and China, the world's two biggest economies.
China has territorial disputes with the Philippines, Vietnam, Taiwan, Brunei and Malaysia over the South China Sea and its potentially oil- and gas-rich islands. Several claimants want group discussions in order to create a legally binding "code of conduct" to prevent clashes in the sea, but Beijing has not clearly stated when it will sit down with the 10-nation ASEAN bloc to discuss such a nonaggression pact.