Kerry will hold talks with Bhutanese Prime Minister Tshering Tobgay from the isolated Himalayan kingdom tomorrow in the northwestern Indian city of Ahmadabad on the sidelines of a trade and investment conference.
While the United States does not have an embassy in Bhutan, the US ambassador to India is accredited to Bhutan as well.
"Secretary Kerry's meeting with Bhutanese Prime Minister Tobgay will mark the first bilateral meeting between a US Secretary of State and a Bhutanese official," a State Department official said in a statement.
Washington and Thimphu have good cooperation, but Bhutan was looking at ways to "deepen our people-to-people ties or our educational ties," another US official told reporters on a conference call.
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The prime minister is a graduate of the University of Pittsburgh and "is quite keen to be able to provide additional opportunities for Bhutanese to be able to study in the United States."
Another important area is regional energy cooperation, the official added.
Thanks to a massive investment in hydropower in the following decade-and-a-half, nearly every household is now hooked up to the electricity grid.
But the radical change in lifestyle has coincided with an equally dramatic transformation of the political system, with the monarchy ceding absolute power and allowing democratic elections in 2008.
With its abundant winding rivers, Bhutan has now set its sights on becoming an energy powerhouse, with most of its electric power already sold to energy-hungry India.