"This is something that both you and I want, and I hope also the Palestinians want," Netanyahu said at the start of his meeting with visiting US Secretary of State John Kerry.
Kerry arrived in Israel today on his fourth trip since he assumed office in February to push for the resumption of peace talks between the Israelis and Palestinians stalled since 2010 over Israel's settlement policy on the occupied land.
"I know this region well enough to know there is scepticism, in some quarters there is cynicism and there are reasons for it. There have been bitter years of disappointment," he said.
"It is our hope that by being methodical, careful, patient, but detailed and tenacious, that we can lay on a path ahead that can conceivably surprise people and certainly exhaust the possibilities for peace," Kerry insisted.
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"We ought to be successful. When there's a will, we'll find a way," the Israeli Prime Minister said.
Netanyahu also noted that they would also discuss the Syria crisis and the Iranian nuclear threat.
He hailed the "extraordinary resolution" overwhelmingly passed by the US Senate yesterday committing Washington's support for Jerusalem in case of nuclear threat from Iran.
The US Secretary is scheduled to meet later today President Shimon Peres and Justice Minister Tzipi Livni, who will be in charge of negotiations with the Palestinians.
This will be Livni's third meeting with Kerry this month, after he met him in Washington and Rome.