Kerry will meet Prime Minister Haider al-Abadi, Foreign Minister Ibrahim al-Jaafari, and Nechirvan Barzani, the prime minister of Iraq's autonomous Kurdish region, State Department spokesman John Kirby said.
He will "underscore our strong support for the Iraqi government as it addresses significant security, economic, and political challenges," Kirby said.
Kerry, who is visiting Iraq for the first time since 2014, will "discuss the (US-led) coalition's continued support for Iraqi-led efforts against" the Islamic State group, Kirby said.
Iraq is battling IS, which overran swathes of territory north and west of Baghdad in 2014, and is also struggling with a financial crisis caused by plummeting world prices for oil, on which it relies for the vast majority of its revenues.
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And Abadi is seeking to replace the current cabinet with a government of technocrats, a move that has faced opposition from powerful parties and politicians that rely on control of ministries for patronage and funds.
Abadi has announced a series of reform measures aimed at curbing government waste and corruption, and improving abysmal public services, but has faced significant opposition behind the scenes, and little in the way of real, lasting change has been accomplished.
Shiite cleric Moqtada al-Sadr, who led an insurgency against US-led troops, organised a sit-in in the heart of Baghdad to keep up the pressure for reform, and Abadi presented the names of proposed candidates to parliament last week.
But some of Abadi's nominees have faced significant pressure to withdraw, and at least one has already done so.
"In terms of the political wrangling in Iraq, it's certainly an issue that concerns us," a State Department official said.
But "the handling of this reshuffle... Is useful, it's needed, because Prime Minister Abadi, from a very early stage in his premiership, has recognised the need for reform."
Iraqi forces have regained significant ground north and west of Baghdad, including Anbar provincial capital Ramadi and Salaheddin capital Tikrit.
Baghdad's forces are now fighting to retake Heet from the jihadists, and have already regained control of some parts of the town.