The 29-year-old singer, who once appeared on "Jane the Virgin", will play herself in an episode of the drama, reported Aceshowbiz.
"Nashville" is no stranger to plucking real musicians to make cameo and the current season four will present country stars Kelsea Ballerini and Thomas Rhett as themselves as well.
Kesha won't be sharing the screen with them and she would appear solo in the second half of the season.
"Nashville" returns with a brand new episode on March 16 after a long winter break.