The 57-year-old Golden Globe Award-winning actor will play the wheelchair-bound photographer convinced he has witnessed a murder, said The Hollywood Reporter.
Based on the Cornell Woolrich short story, the play will have its world premiere at Hartford Stage in October.
Darko Tresnjak, who won a Tony Award in 2014 for "A Gentleman's Guide to Love and Murder" will stage the production.
"I read Cornell Woolrich's classic crime story 'Rear Window' in high school, and it made a lasting impression. I'm thrilled to have the opportunity to direct a stage version 30 years later, when the issues of surveillance and voyeurism have become even more pertinent," Tresnjak said.
Additional cast is yet to be announced.