Khloe, 28, explained in a statement that Odom used the money from his charity foundation Cathy's Kids to help underprivileged children and there were no problems with authorities, reported Ace Showbiz.
"It is unfortunate that my husband has been the target of an attack on athletes' charities, although he has personally contributed approximately USD 2.2 million to his foundation, Cathy's Kids, to fulfil its charitable purposes that include helping underprivileged inner-city youth," she wrote.
"The millions of dollars personally contributed by Lamar constituted more than 90 per cent of the money raised by the foundation. All of the funds donated by Lamar and the other contributions to Cathy's Kids were used for one of the foundation's intended charitable purposes. Not one penny went to help Lamar personally or any member of his family," she added.
The charity was originally established to "help underprivileged kids and raise money for cancer research."
Previously, ESPN's "Outside the Lines" made a report which was based on investigation, saying that Cathy's Kids did not give a single cent to cancer-related causes since 2004.
The report also said that 60 per cent of the USD 2.2 million fund was used to to help two elite basketball travel teams.