Guests for the series finale include Kanye West, Kim Kardashian, John Legend and Chrissy Teigen.
The show will end its run at 14 episodes. Guests on the show are typically drawn from the host's social circle and family, and have included Kendall Jenner, Snoop Dogg, Aisha Tyler, "Real Housewives" star Brandi Glanville and chef Sharone Hakman, reported Variety.
"FYI and Pilgrim Media Group appreciate everyone's great work on the series and are pleased that the show brought new viewers and significant numbers to FYI's linear and digital platforms," FYI and producer Pilgrim Media Group said in a statement.
The move to cancel the show comes three months after FYI upped its episode order from an initial eight episodes to a total of 23.
The show's January 10 debut was the highest rated series premiere in the network's history.
A+E Networks shuttered cable channel Bio in 2014 and relaunched it as FYI. The new network, targeting millennials and upscale adults 25-54, has experienced steady ratings growth since the rebrand.