61-year-old Kher, who made her maiden electoral fray from Chandigarh seat, polled 1,91,362 votes while Congress's Pawan Kumar Bansal got 1,21,720 votes, election office said.
Aam Aadmi Party (AAP) candidate and Bollywood actress Gul Panag secured third position with 1,08,679 votes while BSP's Jahan-ul-Haq was at fourth position with 15,934 votes.
Kher asserted herself with a lead in the first round of counting and continued to maintain it in all the 20 rounds of counting, as per election office.
As many as 3,106 voters (0.68 per cent of the total votes) in Chandigarh opted for None of The Above (NOTA) option, as per election office.
Panag, testing electoral waters for the first time, managed to get considerable chunk of votes which appeared to cast a shadow on the prospects of Bansal.
A total of 17 candidates were in fray from Chandigarh Lok Sabha seat which witnessed 73.84 per cent or 4.53 lakh voters of the 6.13 lakh eligible exercising their franchise on April 10.