Harington, 28, is joining Guy Pearce and Dakota Fanning in the thriller written and directed by Martin Koolhover.
His "Game of Thrones" co-star Carice van Houten also joins the cast along with Paul Anderson, Jack Roth and Carla Juri.
Principal photography has just started and the film will shoot on location in Romania, Spain and Germany.
Harington will play "an outlaw who has a crucial role in the tale of retribution" while Dakota will star as Liz, "a heroine on the run from her past and chased by the evil Preacher (Guy)".
Harington will next be seen in upcoming HBO tennis mockumentary "7 Days in Hell" alongside Adam Samberg.
Meanwhile, Pattinson, who has two upcoming films "Life" and "Queen of the Desert" released later this year, will be working on his next movies "The Lost City of Z" and "The Trap".