Fawkes led a group of provincial English Catholics, who planned the failed Gunpowder Plot of 1605.
The thriller, which has the working title "Gunpowder", is based on the Gunpowder Plot made to blow up the Houses of Parliament in London and to kill King James I, reported Variety.
Endemol Shine's Kudos will produce the show with 29-year-old Harington's Thriker Films. The miniseries will comprise three hour-long episodes.