Many fans took to social media to decry the gender bending and Wiig, 42, was "bummed" about the gender-centric controversy, reported Variety.
"The fact there was so much controversy because we were women was surprising to me. Some people said some really not nice things about the fact that there were women. It didn't make me mad, it just really bummed me out. We're really honoring those movies," she said.
Paul Feig, who is directing the reboot, had a similar experience after the film was announced.
Kate McKinnon, Melissa McCarthy and Leslie Jones will star along with Wiig in the new "Ghostbusters," which will hit the theaters on July 22, 2016.