She underwent the surgery for early-stage lymphoma in London yesterday and is expected to stay at the hospital for at least a day before doctors discharge her, Geo News reported.
"We are grateful to Allah Almighty for successful surgery of Kalsoom bhabi ... May she get well soon!" Sharif's brother and Punjab province's Chief Minister Shehbaz Sharif tweeted.
The former first lady, in her mid-60s, is being tipped as the next prime minister of Pakistan, replacing Shahid Khakan Abbasi.
Sharif reportedly pitched his wife to stage his come back in the prime minister's house as 'first gentleman'.
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Kulsoom has missed campaiging for the by-election due to the surgery. But her daughter, Maryam Nawaz, chose to stay in Pakistan to run Kulsoom's election campaign while her siblings - Hasan, Hussain and Asma - are in London.
During the surgery, Maryam had tweeted: "Ami (mother) in surgery at the moment. Request you all to pray for her. Thank you."
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