Bolstering its chances at the Oscars next month, the movie picked up trophies in all the categories it was nominated for.
The awards ceremony last night, which officially kicks off the Hollywood award season, was predictable when it came to honouring the most loved film this year -- "La La Land".
"La La Land", about two struggling artistes finding love in Hollywood, took home Globes for best comedy/musical, best acting gongs for its lead pair Ryan Gosling and Emma Stone in the same category while Damien Chazelle took home directing and screenplay statuettes. The best original score and song were its other honours.
Streep, this year's Cecil B DeMille Award winner at Golden Globes, tore down Trump in a politically-charged speech as she made a passionate appeal for inclusivity, a running theme of the night.
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She said the "performance" that stood out this year did not belong to an actor but to Trump when he publicly mocked a disabled reporter.
"It kind of broke my heart when I saw it, and I still can't get it out my head because it wasn't in a movie, it was in real life. That instinct to humiliate when it's modeled by someone in a public platform, it filters down into everyone's life because it gives permission for others to do the same," she said.
"If Eva had not taken all that on so I could have this experience, there would be surely someone else standing here today," he said.
An emotional Stone said "La La Land" is "for dreamers" and anyone who "had a door slammed at their face".
Chazelle, a rising young talent in Hollywood, said, "I'm in daze now, officially."
Isabelle Huppert pulled off an upset win in the best actress in a motion picture - drama for "Elle" over favourites Natalie Portman ("Jackie") and Amy Adams for "Arrival". Ruth Negga and Jessica Chastain were other nominees. Huppert's French movie "Elle" was named the best foreign film.
Casey paid tribute to his director Kenneth Lonergan.
"I don't have enough time to say what I want to say about Kenny. So, suffice it to say I love you, you are beautiful, you are a treasure to all of us who like movies and work in movies," he said.
In the best supporting actor and actress categories, the trophies went to Aaron Taylor-Johnson of "Nocturnal Animals", who beat nominees like British-Indian Dev Patel "Lion", Mahershala Ali for "Moonlight", Jeff Bridges for "Hell or High Water" and Simon Helberg for "Florence Foster Jenkins".
Viola Davis predictably won in the best supporting actress category for playing conflicted homemaker in "Fences".