Gaga, 26, took to Twitter to vent out her anger against Harris, reported Daily Mail online.
"Seems to be trendy lately to talk bad about Lady Gaga when your albums/singles drop. You all should live off your own hustle (sic)," Gaga wrote.
"Never even emailed you @calvinharris I guess it's hard to believe I write + produce my music. Because I'm a woman I don't know about EDM right?," she added.
Harris, 28, immediately replied explaining himself and apologised.
"@ladygaga no your label emailed me. I always make sure I say I am a fan when asked about it, I apologise if I offended you, wasn't the intention," he wrote.