The fashionista, 29, enlisted the help of some of her closest couture confidants for the special issue, including Nick Knight, Steven Klein and Inez and Vinoodh, reported People magazine.
"This issue of V is about all of these people coming together to express a passion for art and fashion, to really 'go there' to make a great statement and to change things," Gaga said.
"I feel like we all share an appetite for living a life of passion and creativity... It's like we all found our immortality through art and fashion... We share that deep spiritual place. These are people who have kept and protected me over the years, because they wanted me to survive... That's part of the message of this issue: we have to carry each other through the decades and take care of one another and honour each other's work.