The "Video Games" singer will be presented with the Trailblazer award at the New York ceremony on December 11 in recognition of the "inspiring and interesting path" her career has taken, reported Billboard magazine.
"Lana Del Rey has done things her way from the moment she first burst on the scene (sic), and continues to make brave and bold choices that defy convention," said awards show boss Janice Min.
"She's a trailblazer from her music to her mystery to her multitude of other interests. She keeps everyone awaiting her next move."