Officials said that mud and boulders fell on the road in the ghat section, around six kilometres away from the Goa check post.
"The incident occurred at 2 AM, as heavy rains lashed the Anmod Ghat section along with Goa last night. The road, which serves as a link between Goa and Karnataka, has been disconnected," a district administration official said.
A thick layer (approximately 3 metres) of mud is lying on the road along with huge boulders, the official added.
District Collector N D Agarwal, along with the disaster management team, has also reached the spot to initiate the task of clearing the road.
This route is used by several hundred vehicles everyday.