Trump also called for unity, asserting that in moments of tragedy and horror, America has always stood united.
"Last night, a gunman opened fire in a large crowd at a country music concert in Las Vegas, Nevada. He brutally murdered more than 50 people and wounded hundreds more. It was an act of pure evil," Trump said in his address to the nation from the White House.
As a mark of respect for the victims of the senseless act of violence, Trump issued a proclamation ordering that the US flag be flown at half-staff at the WhiteHouse and other federal buildings.
Trump said he would be travelling to Las Vegas on Wednesday to meet with law enforcement, first responders and the families of the victims. Trump will travel to Puerto Rico tomorrow.
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"Hundreds of our fellow citizens are now mourning the sudden loss of a loved one: a parent, a child, a brother or sister. We cannot fathom their pain. We cannot imagine their loss.
At least 58 people were shot dead and more than 500 others injured when a gunman went on a shooting rampage during a music festival in the casino city of Las Vegas, an FBI special agent said.
"Scripture teaches us the Lord is close to the brokenhearted, and saves those who are crushed in spirit. We seek comfort in those words, for we know that God lives in the hearts of those who grieve.
The FBI has joined the investigations.
The gunman identified as Steven Paddock, 64, was a local Las Vegas resident, was killed in a 32nd floor of a hotel room. The police have also located an Asian female identified as Marilou Danley, 41, who has been described as roommate of the shooter.
The police said they received first reports of active shooting from a Mandalay Bay Hotel towards a musical concert taking place across the road.
"We call upon the bonds that unite us: our faith, our family and our shared values; we call upon the bonds of citizenship, the ties of community, and the comfort of our common humanity," he said.
"Our unity cannot be shattered by evil. Our bonds cannot be broken by violence. And though we feel such great anger at the senseless murder of our fellow citizens, it is our love that defines us today, and always will, forever," he said.
"We pray for the entire nation to find unity and peace. And we pray for the day when evil is banished, and the innocent are safe from hatred and from fear," he said.
"My warmest condolences and sympathies to the victims and families of the terrible Las Vegas shooting," Trump had tweeted earlier.
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