Nearly 12,000 Americans have been killed by guns in 273 mass shootings in 2017 so far one incident for each day.
On an average, more than 90 Americans lose their lives to gun violence every day, a daily toll of heartbreak and tragedy in communities across the US.
Experts believe that the last night incident, which President Donald Trump termed as an "act of pure evil", is unlikely to bridge the bitter differences between the pro- and anti-gun control law lobbies in the country.
Responding to questions, White House Press Secretary Sarah Sanders said today that is the day of reflection and mourning and not a day to discuss political issues.
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Referring to Chicago, she said gun control laws have not been helpful.
Taking a lead, Congresswoman Nancy Pelosi, the Democratic leader, sought off a letter to House Speaker Paul Ryan on creation of a Standing Committee on gun violence and passage of a common-sense legislation on gun control.
The Congress, she said, must pass the bipartisan King- Thompson legislation to strengthen the life-saving background checks that keep guns out of the wrong hands.
But this is only a first step, she said.
"I urge you to create a Select Committee on Gun Violence to study and report back common sense legislation to help end this crisis. The bipartisan committee would make recommendations to prevent unspeakable tragedies such as the mass shooting in Las Vegas and to restore confidence in the safety of our communities," Pelosi said.
"The sorrow that I and so many around the country feel for the innocent men and women whose lives were cruelly cut short by this heartless act of domestic terrorism is immeasurable".
Congressman Earl Blumenauer said: "From Orlando to Roseburg, OR and now Las Vegas, the carnage has only continued. Thoughts and prayers will not stop future tragedy. Enough is enough. My hope is that sanity will prevail, and Republican leadership in Congress will muster up the courage to act".
Over two years ago, he had released a comprehensive plan to deal with gun violence like the public health epidemic that it is, the lawmaker said, adding that the solutions should not be hard.
Congressman Andre Carson said it is time people need to stop hiding behind the false narrative that enacting common sense gun policies somehow limits the rights of law abiding Americans.
"Every day that we fail to act puts more innocent lives at risk. It is long past time to fix our gun laws. Congress has a moral responsibility to act and address the daily tragedy of gun violence in our communities," he said.
In light of the tragedy in Las Vegas, and the ongoing tragedy of gun violence in America, this could not be more inappropriate. The American people deserve a vote on legislation that will curb gun violence, including reinstating an assault weapons ban and instituting new restrictions on gun trafficking, Carson said.
Congressman Alcee L Hastings said that more than 33,000 people will die from gun violence this year.
"With each new tragedy that occurs, those who stand in the way of legislation to address our country's gun violence epidemic are increasingly culpable for its continuation," he said.
Acts of mass gun violence, reported The Washington Post, "have done little to change the strong partisan divide on the issue".
Most Democrats argue that the incidents heighten the need for tighter gun laws, while most Republicans think Americans should have a greater ability to protect themselves, the daily said.