The benchmark resumed higher at 28,805.22 and shot up to 28,978.74 on initial buying in line with global markets that saw a relief rally on the overnight US Fed decision.
The Fed after a closely watched two-day meeting issued a statement that had removed a pledge to remain "patient" on raising rates, signaling a possible mid-year rate increase.
However, Fed chief Janet Yellen emphasised that while jobs were picking up the economy was more muted than 3 months ago, adding that consumer spending slipped and inflation slowed.
Shares of Axis Bank, SBI, ICICI Bank, BHEL, RIL and ITC faced heavy selling among Sensex constituents.
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"Despite positive global cues, equity benchmarks concluded the session with a cut. They failed to capitalise the initial push, which was triggered in response to the US Fed's balanced statement on interest rate hike," said Jayant Manglik, President-retail distribution, Religare Securities.
Emerging markets were jittery in the run-up to the Fed policy meeting outcome as any unexpected decision on rate hike can lead to flight of capital from riskier assets.
Key indices in China, Hong Kong, Taiwan, Singapore and South Korea were up 0.14 per cent to 1.45 per cent while in Japan, the Nikkei 225 index fell by 0.35 per cent.
European markets were also trading higher as key indices in France, Germany and the UK moved up by 0.23-0.25 per cent.