Only eight out of 25 ministerial posts had been filled nearly eight months after Ghani's inauguration and the formation of a "national unity government" with his poll rival Abdullah Abdullah.
The rest were rejected by parliament in late January over technicalities, despite a power-sharing deal agreed between Ghani and Abdullah.
Though the deal was seen as staving off the threat of civil war, the delays stoked fears of instability in the troubled nation as NATO troops pull back from the frontlines after 13 years of conflict against the Taliban.
Today a suicide bomber tore through a crowd of people, including government employees outside a bank in eastern city of Jalalabad, killing at least 33 people and wounding more than 100 others.
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The Islamic State group claimed responsibility for a attack, Ghani said, in what appears to be the first major attack by the jihadists in the country.
Among the 16 cabinet nominees endorsed today were four women, leading the ministries of education, counter-narcotics, labour and women's affairs.