Former President Jacques Chirac and current leader Francois Hollande have both apologised for the role French police played in the round-up of more than 13,000 Jews at the Vel d'Hiv cycling track which was ordered by Nazi officers in 1942.
But Le Pen told the LCI television channel today: "I don't think France is responsible for the Vel d'Hiv."
She added: "I think that generally speaking if there are people responsible, it's those who were in power at the time. It's not France."
"So, I want them to be proud of being French again," she said.
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Ahead of the first round of France's highly unpredictable presidential election on April 23, Le Pen's centrist rival Emmanuel Macron said her comments were "a serious mistake".
"Some had forgotten that Marine Le Pen is the daughter of Jean-Marie Le Pen," Macron told BFMTV.
Le Pen Senior, who founded the FN in 1972 and is estranged from his daughter, has been convicted repeatedly for anti-Semitic and racist comments such as calling the Holocaust a "detail of history".
The CRIF umbrella grouping of French Jewish organisations and the Jewish students' union (UEJF) both blasted Le Pen for the comments, describing them as "revisionist".
"These remarks are an insult to France, which honoured itself in 1995 by recognising its responsibility in the deportation of France's Jews and facing its history without a selective memory," the CRIF said.
Chirac's Socialist predecessor Francois Mitterand had refused to acknowledge responsibility for the deportations, saying in 1994: "The republic had nothing to do with that. France is not responsible.