The letter comes in the midst of an exodus of senior-level executives from India's second-largest software services firm, including board members B G Srinivas, V Balakrishnan and Ashok Vemuri.
"...As we embark onto newer and better horizon for our employees and our clients, we will see some transition in leadership. Please rest assured that the leadership changes take into account the best interest of the company as a whole," Murthy, who is Executive Chairman, said in his letter.
Earlier this week, board member and President Srinivas resigned from the Bangalore-based firm in a surprise move, after a 15-year stint. He will join Hong Kong-based diversified group PCCW as Group MD.
Srinivas was considered to be among the top contenders for the CEO's post when S D Shibulal retires on January 9.
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With his exit, the chances of an outsider taking over as CEO of Infosys have brightened.
He added that in the interim, Shibulal will manage Srinivas' portfolio.
Assuring the employees, he said the company remains focused on its mission to perform and grow.
"The Nomination Committee, selection process for the new CEO is progressing as planned. The new CEO will be announced at the conclusion of the process," he said.
He added that while the search is on, he, Shibulal and Executive Vice Chairman S. Gopalakrishnan, along with the Infosys board, will steer the company.