The music video which debuted on Friday shows naked lookalikes of celebrities in bed alongside West and his wife, Kim Kardashian.
Dunham, 30, took to Facebook to share "some disjointed thoughts" on the clip.
The "Girls" creator said it is one of the most disturbing artistic efforts and called it an emblematic of rape culture.
"As assaults are Periscoped across the web and girls commit suicide after being exposed in ways they never imagined ... While Bill Cosby's crimes are still being uncovered and understood as traumas for the women he assaulted but also massive bruises to our national consciousness ...
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The actress, whose parents are both artists, refused to accept "Famous" as a provocative work of art.
"If it's been banned, I'll probably love it. Because I know that art's job is to make us think in ways that aren't always tidy or comfortable.
"But this feels different. It makes me feel sad and unsafe and worried for the teenage girls who watch this," she added.
"Here's the thing, Kanye: you're cool. Make a statement on fame and privacy and the Illuminati or whatever is on your mind! But I can't watch it, don't want to watch it, if it feels informed and inspired by the aspects of our culture that make women feel unsafe even in their own beds, in their own bodies.