The 39-year-old actor was earlier reported to make the much-awaited project but has now completely disassociated from the untitled movie, said The Hollywood Reporter.
DiCaprio, after finishing 'The Revenant' has apparently planned to take a lengthy break from acting.
Scott Rudin is producing alongside Film 360's Guymon Casady and Mark Gordon. The Jobs film would have marked a reteaming of DiCaprio and Danny Boyle, who previously teamed on 2000's 'The Beach'.