The 40-year-old "Wolf of Wall Street" star will be handed the coveted accolade at the SAG Foundation's 30th Anniversary Celebration at the Wallis Annenberg Center for the Performing Arts in Beverly Hills on November 5
He will be recognised for his on-screen achievements, including eight SAG nominations and five Oscar nominations - and his charity work through the Leonardo DiCaprio Foundation, which was founded in 1998 and has donated over $30 million toward environmental causes.
"To commemorate our landmark anniversary, we're excited to honour Leonardo DiCaprio's outstanding achievements with our Actors Inspiration Award," said SAG Foundation President JoBeth Williams.
The actor is "honoured" to be receiving the award and is "proud" to be associated with the organisation.
"It is an honour to be recognised by the SAG Foundation, a group which does so much to support, sustain, and educate my fellow actors and give back to the entertainment industry, as well as the work it has done to advance children's literacy," he said in a statement.