Crick used the handwritten note to tell his 12-year-old son Michael that he and his colleague Jim Watson had "probably made a most important discovery", written weeks before the public announcement in 1953.
The seven-page handwritten letter expresses Crick's personal excitement of the recognition of the double helix structure of DNA, the building block of life.
Michael, who was at a British boarding school, was instructed to "read this carefully so that you understand it. When you come home we will show you the model."
"Our structure is very beautiful...Now we believe that the DNA is a code. That is, the order of the bases (the letters) makes one gene different from another gene (just as one page of print is different from another)...In other words we think we have found the basic copying mechanism by which life comes from life.
In 1962, Crick, Watson and Maurice Wilkins received the Nobel Prize in medicine for discovery of the structure and function of DNA at the Cavendish Laboratory and at the University of Cambridge, the statement said.
On April 10, Christie's New York will offer the letter from Crick, the co-discoverer of the structure and function of deoxyribonucleic acid (DNA), to his son, outlining the revolutionary discovery, dated March 19, 1953.