"Our nation is committed to the principle that all people should be treated fairly and with respect," the US President said in a statement on the occasion of International Day Against Homophobia and Transphobia.
"Advancing this goal has long been a cornerstone of American diplomacy, and I am proud that my Administration has made advancing the human rights of LGBT individuals a specific focus of our engagement around the world," he said.
He also lauded the efforts the US made in recent years in marriage equality of lesbian, gay, bisexual, and transgender (LGBT) community.
At the same time, there is much work to be done to combat homophobia and transphobia, both at home and abroad, Obama said.
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"In too many places, LGBT individuals grow up forced to conceal or deny who they truly are for fear of persecution, discrimination, and violence.
All nations and all communities can, and must, do better," he noted.
"Fortunately, human rights champions and good citizens around the world continue to strive towards this goal every day by lifting up the simple truth that LGBT rights are human rights. The US honours their work and will continue to support them in their struggle for human dignity," Obama said.