The rapper, 33, and his entourage were flying from Milwaukee to California when he blacked out from an apparent seizure, reported TMZ.
Wayne allegedly refused treatment when paramedics arrived to the airport.
The plane took off, but was forced to return when Wayne suffered a second seizure and was taken to CHI Health Creighton University Medical Center.
This isn't the first time Wayne has suffered an epileptic fit.
In 2013, Wayne, born Dwayne Carter Jr, was hospitalized several times after suffering from seizures believed to be brought on by drinking a drink that combines soda with prescription cough syrup.