Helicopter footage from the scene captured authorities hauling items from 33-year-old Wayne's house into a truck, including what appeared to be wrapped artwork.
Last month, Signature Group successfully sued Wayne for USD 2 million over missed payments.
At the time, according to court documents obtained, Miami-Dade County Judge Lisa S Walsh denied Signature's request for a "break order" - which would allow police to enter Wayne's house with or without permission - because the group couldn't prove there were valuable assets on the premises.
Her decision was partially based on an affidavit from a real estate agent who, according to Signature's suit, "had recently been inside the defendant's home and attested that there was assets inside."
Neither Wayne, nor a representative for the rapper, has yet to comment on the raid or repossession.