The "Lollipop" hitmaker was in the middle of belting out the lyrics to his hit "A Milli" on Sunday, when he was pelted with a bottle of booze by a crowd member, which made him storm off stage, reported TMZ.
The incident was captured on camera and, although he wasn't directly hit by the bottle, he did seem to have some splash marks over his clothes when he walked off.
The crowd broke out into boos but Wayne made it clear that he wasn't prepared to put up with that type of behaviour.
"Show over, man. Those in the building just ruined y'all time. Show over.