The mishap occurred when the 10-wheeler lorry, coming from Chennai and carrying about 900 cases of liquor, consisting of brandy and whisky, meant for Tamil Nadu State Marketing Corporation bars in the district, had stopped near Kandal, police said.
As the driver started the vehicle, a two-wheeler came in front and the driver slammed the brakes and the vehicle overturned and fell into the drainage.
The driver fled the scene immediately, as the load was worth around Rs 35 lakh, police said.
As people thronged the spot, six policemen were posted to prevent them from laying hands on the bottles.
Meanwhile, the administration has requisitioned a crane to lift the lorry from the drainage, which has started getting clogged, police said.