The two bands both rule the charts with their catchy tunes and have a similar history when it comes to band beginnings.
Both were formed on "The X Factor", with Little Mix coming together on the British version in 2011 and Fifth Harmony emerging from the short-lived US show the following year.
When asked if they would be up for joining forces to create the ultimate super group, Little Mix singer Perrie Edwards said she would jump at the chance, reported Metro.
"Yes! Imagine the sass," Edwards said, while bandmate Jade Thirlwall added: "The hair whips would be off the scale."