Liverpool can rub more salt into Manchester United wounds with a first victory at Old Trafford in five years on Sunday, while Manchester City will try to haul themselves back onto the leader's coattails with victory at Crystal Palace.
Just eight games into the season, 15 points separates Liverpool at the top of the table from United down in 12th.
The European champions have shot into an eight-point lead even over their closest challengers in City, thanks to a run of 17 straight Premier League wins stretching back to last season.
By contrast, United have won just two of their last 13 league games. Injury problems that have contributed to the Red Devils' early season struggles have struck again with influential duo Paul Pogba and David de Gea absent.
However, Ole Gunnar Solskjaer has called on his players to rise to the occasion of a clash between the two most successful sides in English football history.
"I always look at the next game as a chance. The Liverpool game is a great chance for us to go the other way," Solskjaer told Sky Sports.
"It's in my nature to think of the best-case scenario. I know the fans and the players will be up for it.
"We need to step up to the plate, and these are the big games that you sign up for at Man United - you have to show your quality."
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