Liverpool face a derby clash against Everton as they lick their Champions League wounds while Tottenham travel to Arsenal with a spring in their step on a weekend of big-city derbies.
Jurgen Klopp's team lost 2-1 to Paris Saint-Germain in midweek, meaning their bid to reach the knockout stages in Europe will go to the last game against Napoli, while Spurs face the daunting task of beating Barcelona to progress.
But both clubs will have to put their continental ambitions to one side as they attempt to stay on the coat-tails of Pep Guardiola's Manchester City in the Premier League.
Chelsea take on Fulham and one of their former managers in another London derby but Claudio Ranieri's side will travel the short distance to Stamford Bridge with new-found confidence after arresting a run of six Premier League defeats.
Jose Mourinho's misfiring Manchester United play Southampton away after edging past Swiss side Young Boys into the Champions League knockout phase. AFP Sports picks out some of the main talking points ahead of the weekend fixtures in the Premier League.
'Perfect' time to play Arsenal
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"It is a game the fans want to win and one that we want to win. Three games in a week is going to be tough, but confidence is high." Everton derby pain
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"This game is isolated from the season," he said. "It's a derby, it's at home. Everton are doing really well this season, they're a completely different cup of tea, I would say, to the last few years so it will be a tough one." Time running out for misfiring United
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