Liverpool can equal Manchester City's record of 20 consecutive home Premier League wins on a weekend that pits six top-four contenders against each other in the scramble for Champions League spots.
Jurgen Klopp's men, champions in all but name after 23 wins in 24 matches, will lock horns with in-form Southampton at Anfield on Saturday with the chance to extend their lead over City to 22 points.
Pep Guardiola's City travel to face Tottenham while third-placed Leicester host Chelsea and Manchester United take on Wolves in an intriguing set of fixtures.
AFP picks out some of the main talking points ahead of this weekend's matches.
Will Fernandes be missing spark for Man Utd?
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"Bruno's goals and assists stats speak for themselves," said the Norwegian boss. "He will be a fantastic addition to our team and he will help us push on in the second part of the season."
Leicester reset after League Cup pain
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"It's all building a great resilience in the squad. Chelsea at King Power Stadium at the weekend, it's a great game for us really, after a game like that."
Pep v Mourinho
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Southampton reap rewards of loyalty
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"Not normal in the positive and not normal in the negative way so I don't expect a normal game from our side at the weekend."