Sheen, 47, and Lohan, 26, reunited for the film to play a dysfunctional couple with legal problems, reported Daily Mirror.
Lohan showed up late for the red carpet when the event was scheduled to close and just before the movie was about to start.
She also got a kiss from her co-star in front of photographers and said, "I'm taking care of myself."
The 'Mean Girls' star wore a sleek Dolce and Gabbana dress with caged black heels and side-swept hair to the screening.