The Speaker of the House of Commons, John Bercow, will bathe the Elizabeth Tower in blue light as part of the global Blue Monument Challenge.
The Mayor of London, Boris Johnson, has agreed to light up the fountains at Trafalgar Square in blue, the colour used to signify diabetes awareness.
"Diabetes affects far too many people in London and across the UK. It is vitally important to raise awareness of a disease that is preventable and treatable and I am delighted to back this campaign," said Johnson.
The Blue Monument Challenge, started in 2007 by the International Diabetes Federation, has seen over 1,000 monuments and buildings in more than 80 countries being lit up in blue.
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Monuments previously covered under this include the London Eye in 2010, the Christ the Redeemer statue of Rio de Janeiro, Table Mountain in Cape Town in 2011 and Number 10 Downing Street in 2012, also on the request of Silver Star.
The units travel to community centres, schools, work places and places of worship to offer free diabetes testing and lifestyle advice. They have so far tested over 36,000 people on two continents.
"Since I discovered I had type-2 diabetes by chance seven years ago, raising awareness for the condition and urging people to have a test has become so important to me," said Silver Star founder-patron Vaz, who is also chair of the influential Home Affairs Select Committee.
There are currently an estimated three million people in Britain with diabetes, with a further 850,000 thought to have the condition yet not be aware.
Britain's South Asian community is believed to be at major risk because of genetic and lifestyle factors.